Pharmaceutical Creams & Gels

Our products enable superior performance in liquid and semi-solid dosage forms.

photo-pharmaceutical-creams-and-gels

Our CAB-O-SIL® M-5P and M-5DP fumed silicas are key excipients in a wide range of pharmaceutical products. In liquid and semi-solid dosage forms, these products provide the following benefits:

  • Stabilization and anti-settling. CAB-O-SIL M-5P and M-5DP untreated fumed silicas can stabilize dispersions of solids in liquids and help prevent the formation of sediments in liquid suspensions.
  • Thickening. CAB-O-SIL M-5P and M-5DP untreated fumed silicas can convert non-polar liquids into spreadable gels. The gels will not melt at body temperature, enabling applications where precise area-dosing is required.
  • Transparency. Clear gels can be formulated if the refractive index of the system matches that of CAB-O-SIL fumed silica (1.46).
  • Stability and uniform distribution. CAB-O-SIL M-5P and M-5DP untreated fumed silicas improve the consistency and stability of suppositories and can increase the softening point without affecting the melting point.
  • Spraying Aid. In topical aerosol products, CAB-O-SIL fumed silica can help to reduce clogs in the atomizer and prevent the formation of sediments.
CAB-O-SIL M-5P fumed silica meets all the requirements for:
  • "Colloidal Silicon Dioxide" in the U.S. Pharmacopeia/National Formulary
  • "Silica, Colloidal Anhdryous" in the European Pharmacopoeia
  • "Light Anhydrous Silicic Acid" in the Japanese Pharmacopoeia

CAB-O-SIL M-5DP fumed silica meets all the requirements for:

  • "Colloidal Silicon Dioxide" as described in the U.S. Pharmacopoeia National Formulary 
  • "Silica, Colloidal Anhydrous" as described in the European Pharmacopoeia

CAB-O-SIL M-5DP fumed silica is currently available in Europe only.